Author: Mercado G1, Brundin P2
1Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
2Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA. Electronic address: Patrik.Brundin@vai.org.
Conference/Journal: Trends Endocrinol Metab.
Date published: 2019 Aug 28
Other: Pages: S1043-2760(19)30157-2 , Special Notes: doi: 10.1016/j.tem.2019.08.001. [Epub ahead of print] , Word Count: 64
A new mouse model of Parkinson's disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits in wild-type mice. These findings support the idea that the gut could be a starting point for PD.
Copyright © 2019 Elsevier Ltd. All rights reserved.
PMID: 31473011 DOI: 10.1016/j.tem.2019.08.001