Lots of Movement in Gut and Parkinson's Research.


Author: Mercado G1, Brundin P2

Affiliation: <sup>1</sup>Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.

<sup>2</sup>Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA. Electronic address: Patrik.Brundin@vai.org.
Conference/Journal: Trends Endocrinol Metab.
Date published: 2019 Aug 28
Other:
  Pages: S1043-2760(19)30157-2   ,  Special Notes: doi: 10.1016/j.tem.2019.08.001. [Epub ahead of print]   ,  Word Count: 64  
    A new mouse model of Parkinson's disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits in wild-type mice. These findings support the idea that the gut could be a starting point for PD.



Copyright © 2019 Elsevier Ltd. All rights reserved.



PMID: 31473011  DOI: 10.1016/j.tem.2019.08.001