Qigong Institute

Vagal afferents contribute to sympathoexcitation-driven metabolic dysfunctions.

Author: Lorenzo-Martín LF^1,^2,³, Menacho-Márquez M^1,^2,³, Fabbiano S^1,², Al-Massadi O^4,^5,⁶, Abad A^1,^2,³, Rodríguez-Fdez S^1,², Sevilla MA^1,², Montero MJ^1,², Diéguez C^4,^5,⁶, Nogueiras R^4,^5,⁶, Bustelo XR^1,²
Affiliation:
¹Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.
²Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.
³Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain.
⁴Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain.
⁵Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain.
⁶Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain.
Conference/Journal: J Endocrinol.
Date published: 2019 Mar 1
Other: Volume ID: 240 , Issue ID: 3 , Pages: 483-496 , Special Notes: doi: 10.1530/JOE-18-0623. , Word Count: 142

Multiple crosstalk between peripheral organs and the nervous system are required to maintain physiological and metabolic homeostasis. Using Vav3-deficient mice as a model for chronic sympathoexcitation-associated disorders, we report here that afferent fibers of the hepatic branch of the vagus nerve are needed for the development of the peripheral sympathoexcitation, tachycardia, tachypnea, insulin resistance, liver steatosis and adipose tissue thermogenesis present in those mice. This neuronal pathway contributes to proper activity of the rostral ventrolateral medulla, a sympathoregulatory brainstem center hyperactive in Vav3-/- mice. Vagal afferent inputs are also required for the development of additional pathophysiological conditions associated with deregulated rostral ventrolateral medulla activity. By contrast, they are dispensable for other peripheral sympathoexcitation-associated disorders sparing metabolic alterations in liver.

KEYWORDS: GABAergic signals; adipose tissue; brainstem; diabetes; hypertension; liver; metabolic syndrome; sympathetic system; thermogenesis; ventrolateral medulla

PMID: 30703063 DOI: 10.1530/JOE-18-0623

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Vagal afferents contribute to sympathoexcitation-driven metabolic dysfunctions.