Author: Lorenzo-Martín LF1,2,3, Menacho-Márquez M1,2,3, Fabbiano S1,2, Al-Massadi O4,5,6, Abad A1,2,3, Rodríguez-Fdez S1,2, Sevilla MA1,2, Montero MJ1,2, Diéguez C4,5,6, Nogueiras R4,5,6, Bustelo XR1,2
Affiliation: <sup>1</sup>Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.
<sup>2</sup>Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.
<sup>3</sup>Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain.
<sup>4</sup>Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain.
<sup>5</sup>Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain.
<sup>6</sup>Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain.
Conference/Journal: J Endocrinol.
Date published: 2019 Mar 1
Other:
Volume ID: 240 , Issue ID: 3 , Pages: 483-496 , Special Notes: doi: 10.1530/JOE-18-0623. , Word Count: 142
Multiple crosstalk between peripheral organs and the nervous system are required to maintain physiological and metabolic homeostasis. Using Vav3-deficient mice as a model for chronic sympathoexcitation-associated disorders, we report here that afferent fibers of the hepatic branch of the vagus nerve are needed for the development of the peripheral sympathoexcitation, tachycardia, tachypnea, insulin resistance, liver steatosis and adipose tissue thermogenesis present in those mice. This neuronal pathway contributes to proper activity of the rostral ventrolateral medulla, a sympathoregulatory brainstem center hyperactive in Vav3-/- mice. Vagal afferent inputs are also required for the development of additional pathophysiological conditions associated with deregulated rostral ventrolateral medulla activity. By contrast, they are dispensable for other peripheral sympathoexcitation-associated disorders sparing metabolic alterations in liver.
KEYWORDS: GABAergic signals; adipose tissue; brainstem; diabetes; hypertension; liver; metabolic syndrome; sympathetic system; thermogenesis; ventrolateral medulla
PMID: 30703063 DOI: 10.1530/JOE-18-0623