Actions of 17β-Estradiol and Testosterone in the Mitochondria and their Implications in Aging.
Author: Vasconsuelo A, Milanesi L, Boland R.
Affiliation:
Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur. San Juan 670, 8000 Bahía Blanca, Argentina. Electronic address: avascon@criba.edu.ar.
Conference/Journal: Ageing Res Rev.
Date published: 2013 Sep 13
Other:
Pages: S1568-1637(13)00064-0 , Special Notes: doi: 10.1016/j.arr.2013.09.001 , Word Count: 139
A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17β-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.
Copyright © 2013. Published by Elsevier B.V.
KEYWORDS:
17β-estradiol, Aging, Androgen receptor, Estrogen receptor, Mitochondria, Testosterone
PMID: 24041489
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