Acupuncture suppresses reinstatement of morphine-seeking behavior induced by a complex cue in rats.
Author: Lee BH, Lim SC, Jeon HJ, Kim JS, Lee YK, Lee HJ, In S, Kim HY, Yoon SS, Yang CH.
Affiliation:
Department of Acupuncture, Moxibustion and Acupoint, College of Oriental Medicine, Daegu Haany University, Daegu 706-828, South Korea. Electronic address: dlqhdgy@dhu.ac.kr.
Conference/Journal: Neurosci Lett.
Date published: 2013 May 18
Other:
Pages: S0304-3940(13)00447-3 , Special Notes: doi: 10.1016/j.neulet.2013.05.026. , Word Count: 185
OBJECTIVES:
Morphine causes physical and psychological dependence for individuals after repeated-use. Above all, our previous study showed that acupuncture attenuated reinstatement of morphine-seeking behavior induced by pharmacological cue. In this study, we investigated whether acupuncture could suppress the reinstatement of morphine-seeking behavior induced by the combination of environmental and phamacological cues and the possible neuronal involvement.
MATERIALS AND METHODS:
Male Sprague-Dawley rats were trained to self-administer morphine (1.0 mg/kg) for three weeks. Following the withdrawal phase (seven days), the effects of acupuncture on reinstatement of morphine-seeking behavior were investigated. For the investigation of neuronal involvement, the GABAA receptor antagonist bicuculline and the GABAB receptor antagonist SCH 50911 were pre-treated.
RESULTS:
Morphine-seeking behavior induced by combination of re-exposure to the operant chamber and morphine injection was suppressed perfectly by acupuncture at SI5, but not at the control acupoint LI5 and this effect was blocked by pre-treatment with the GABA receptor antagonists.
CONCLUSIONS:
This study suggests that acupuncture at SI5 can be considered as a predominant therapy for the reinstatement of morphine-seeking behavior in humans.
Copyright © 2013. Published by Elsevier Ireland Ltd.
PMID: 23693124 [PubMed - as supplied by publisher]
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