[Electroacupuncture at Guanyuan (CV 4) and Zhongwan (CV 12) modulates functional connectivity of the brain network in healthy volunteers].

Author: Fang JL, Hong Y, Wang XL, Liu HS, Wang Y, Liu J, Wang L, Xue C, Zhou KH, Song M, Liu BY, Zhu B.
Affiliation: Department of Radiation, Guang'anmen Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing 100053, China. fangmgh@gmail.com
Conference/Journal: Zhen Ci Yan Jiu.
Date published: 2011 Oct
Other: Volume ID: 36 , Issue ID: 5 , Pages: 366-72 , Special Notes: [Article in Chinese] , Word Count: 257


OBJECTIVE:
To observe the specific brain effects of electroacupuncture (EA) stimulation of Guanyuan (CV 4) and Zhongwan (CV 12).
METHODS:
Twenty-one healthy volunteers were recruited in the present study. Two silver filiform needles were separately inserted into Guanyuan (OV 4) or Zhongwan (CV 12), and manipulated with uniform reducing-reinforcing method to induce "Deqi". fMRI scan was performed before needling, during needle retention, EA stimulation, and post-EA. Data of fMRI was analyzed by using software SPM 2. The volunteer subjective needling sensations were recorded. The activation, deactivation, short-distance and long-distance functional connectivity maps of different cerebral regions were analyzed by using whole brain correlation analysis.
RESULTS:
Comparison between the two acupoints showed that fullness feeling was stronger in CV 4 than in CV 12. EA at CV 4 and CV 12 induced a similar stronger and prevalent deactivation in the ventral medial prefrontal cortex and the anterior cingulated cortex (ACO). The deactivation of the ACC was stronger in the CV 4 group than in the CV 12 group. The default BOLD mode of the brain at rest was modified by needle retention and EA, respectively. The short-distance functional connection brain network was significantly changed after EA. Interestingly, the ventral medial prefrontal cortex and anteroinferior portion of the anterior cingulate cortex in the limbic-paralimbic-neocortical network (LPNN) were involved in the instant post-effects of EA. Relatively smaller differences in the brain functional activity and short-distance functional connectivity were found between these two acupoints.
CONCLUSION:
EA of CV 4 and CV 12 can modulate short-distance functional connectivity of the LPNN, and have fewer differences in inducing needling sensation and deactivation of ACC, etc.
PMID: 22073890

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