Effects of Corydalis Tuber on synthesis of NO and PGE2in murine macrophage RAW 264.7 cells stimulated by LPS
Author: Lee Ki-Young 1//Park Sung-Ho 1//Kim Jeongseon 2//Jang Mi-Hyeon 3////
Affiliation:
Department of Acupoint & Meridians, College of Oriental Medicine, Semyung University, Jechon, Korea [1]//Department of Food & Nutrition in Oriental Medicine, College of Oriental Medicine, Semyung University, Jechon, Korea [2]//Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea [3]////
Conference/Journal: J Intl Soc Life Info Science
Date published: 2004
Other:
Volume ID: 22 , Issue ID: 2 , Pages: 512 , Word Count: 102
Corydalis Tuber has traditionally been used for the treatment of pain and arthritis. The effect of Corydalis Tuber against lipopolysaccharide-induced inflammation was investigated using reverse transcription-polymerase chain reaction (RT-PCR), nitric oxide detection, and prostaglandin E2 (PGE2) immunoassay on murine macrophage RAW 264.7 cells. The aqueous extract of Corydalis Tuber suppressed nitric oxide production and PGE2 synthesis by inhibition on the lipopolysaccharide-stimulated enhancement of the inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and interlukin-1beta (IL-1beta) mRNAs expressions in RAW 264.7 macrophages. These results suggest that Atractylodes japonica exerts anti-inflammatory and analgesic effects probably by suppression of the iNOS, COX-2, and IL-1beta expressions.
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