Author: Zhang GM//Hao TL//Yang YZ//Feng ZH////
Department of Molecular Biology, Tongji Medical University, Wuhan
Conference/Journal: Journal of Tongji Medical University
Date published: 1992
Other: Volume ID: 12 , Issue ID: 3 , Pages: 150-3 , Word Count: 110
Effects of Chinese Medicinal Preparation 'Re Du Qing' (RDQ) on the activation, proliferation and membrane fluidity of T lymphocytes from human peripheral blood were studied by means of 3H-TdR incorporation and DPH fluorescence polarization. The results showed that 'RDQ' can: 1) significantly inhibit the activation of T lymphocytes; 2) restrain the proliferation of activated T lymphoblasts in the presence of exogenous interleukin-2 (IL-2); and 3) increase the membrane fluidity of T lymphocytes and antagonize the decreased fluidity of lymphocyte membrane mediated by Con A or PHA. The functional abnormalities of T lymphocytes in some autoimmune diseases such as arthritis and the usefulness of RDQ in the treatment of these diseases were also discussed.