Interaction between Mind-Heart and Gene

We hypothesize that mind-heart and genes influene each other, and review recent studies to support this hypothesis. 1. regarding the action of genes on mind-heart, a relationship between personality and gene structure has been reported. It has been shown that individuals with a large number of repeat sequences in the dopamine receptor gene eagerly seek novelty, while those with a small number of repeat sequences in the promoter of the serotonin transporter gene tend to feel anxiety. 2. It has been reported that mental stress influences the expression (ON/OFF) of the genes foe neuroendoctorine-immune factors 8CRH, POMC, IL-2R) and the expression of the genes for factors (c-myc, c-myb, c-fos, c-jun) related to cell growth and differentation, thereby suppressing the immune response and enhancing resistance to stress. Precise mechanisms of the interaction between mind-heart and genes will be elucidated in the future through progress of the exhaustive analysis of the expression profile of genes that are switched ON/OFF by various factors influencing mental activity.