Repetitive Transcranial Magnetic Stimulation and Tai Chi Chuan for Older Adults With Sleep Disorders and Mild Cognitive Impairment: A Randomized Clinical Trial

Importance:
Sleep disorders and mild cognitive impairment (MCI) commonly coexist in older adults, increasing their risk of developing dementia. Long-term tai chi chuan has been proven to improve sleep quality in older adults. However, their adherence to extended training regimens can be challenging. Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulation technique that may enhance the benefits of exercise.

Objective:
To investigate whether 1-Hz rTMS of the right dorsolateral prefrontal cortex could enhance the clinical benefits of tai chi chuan in improving sleep quality and cognitive function among older adults with sleep disorders and MCI.

Design, setting, and participants:
This 2-arm, sham-controlled, assessor-masked randomized clinical trial was conducted at a university hospital in China between October 2022 and February 2024. Adults aged 60 to 75 years with sleep disorders and MCI were eligible. Data analysis was performed from February to May 2024.

Intervention:
Participants were randomized in a 1:1 ratio to an experimental group (tai chi chuan and 1-Hz rTMS) or a sham group (tai chi chuan and sham rTMS). Each participant received 30 sessions of personalized rTMS targeting the right dorsolateral prefrontal cortex, and the sham group underwent the same procedure. The 2 groups received 30 sessions of 60 minutes of the 24-form simplified tai chi chuan, 5 times per week for 6 weeks.

Main outcomes and measures:
The primary outcomes were subjective sleep quality assessed by the Pittsburgh Sleep Quality Index (PSQI), in which scores range from 0 to 21, with lower scores indicating a healthier sleep quality, and global cognitive function assessed by the Montreal Cognitive Assessment (MoCA), in which scores range from 0 to 30, with higher scores indicating less cognitive impairment. The secondary outcomes included measures of objective sleep actigraphy, anxiety and depression scales, and other cognitive subdomains. Assessments were performed at baseline, 6 weeks after the intervention, and at the 12-week follow-up.

Results:
A total of 110 participants (mean [SD] age, 67.9 [4.6] years; 68 female [61.8%]) were randomized to the experimental group (n = 55) and the sham group (n = 55) and included in the intention-to-treat analysis. At 6 weeks after the intervention, compared with the sham group, the experimental group showed a lower PSQI score (between-group mean difference, -3.1 [95% CI, -4.2 to -2.1]; P < .001) and a higher MoCA score (between-group mean difference, 1.4 [95% CI, 0.7-2.1]; P < .001). The per-protocol dataset analyses and 12-week follow-up showed similar results. The generalized estimated equation model revealed an interaction effect between the PSQI score (mean difference, -2.1 [95% CI, -3.1 to -0.1]; P < .001) and the MoCA total score (mean difference, 0.9 [95% CI, 0.1-1.6]; P = .01). There were 7 nonserious, unrelated adverse events (experimental group: 2; sham group: 5) with no significant difference between the 2 groups.

Conclusions and relevance:
In this randomized clinical trial, the findings suggest that 1-Hz rTMS enhanced the clinical benefits of tai chi chuan in improving sleep quality and cognitive function among older adults with sleep disorders and MCI, which may be related to alterations in neural plasticity. These findings provide novel data on nonpharmacologic strategies for the rehabilitation of sleep disorders and may delay or even prevent MCI.

Trial registration:
Chinese Clinical Trial Registry Identifier: ChiCTR2200063274.


PMID: 39792383 DOI: 10.1001/jamanetworkopen.2024.54307