Cardiac vagal control and inflammation are upregulated in exceptional human longevity
Author: Gabriel Dias Rodrigues1, Domenico Azzolino2, Valentina Manzini1, Marco Proietti1,3, Angelica Carandina1, Costanza Scatà1, Chiara Bellocchi1,4, Eleonora Tobaldini1,4, Evelyn Ferri2, Beatrice Arosio1, Matteo Cesari1, Nicola Montano5,6
Affiliation:
1 Department of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
2 Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122, Milan, Italy.
3 Division of Subacute Care, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy.
4 Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milan, Italy.
5 Department of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy. nicola.montano@unimi.it.
6 Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milan, Italy. nicola.montano@unimi.it.
Conference/Journal: Intern Emerg Med
Date published: 2024 Dec 27
Other:
Special Notes: doi: 10.1007/s11739-024-03837-8. , Word Count: 143
We investigated the interplay of cardiovascular autonomic and inflammatory profiles in persons with extreme longevity (PEL), their direct offsprings (DO), and a group of controls matched for age and sex with the DO. Cardiac autonomic control was assessed through the heart rate variability (HRV) using spectral and symbolic analysis. The plasma concentration and gene expression of interleukin (IL)-10, IL-6, and TNF-α were quantified. In PEL, the sympatho-vagal is shifted to a vagal predominance and both pro- and anti-inflammatory circulation cytokines are increased compared to DO and controls. Also, no differences were found in HRV between DO and controls. These preliminary results suggest that environmental factors, at least in our small sample, may overcome the impact of heritability on cardiac autonomic control and inflammatory circulation cytokines.
Keywords: Autonomic nervous system; Heart rate variability; Inflammaging; Longevity; Low-grade inflammation.
PMID: 39730986 DOI: 10.1007/s11739-024-03837-8
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