Clinical and Basic Research on Biological Medicine Amalgamated with Western Medicine Causes and Treatment of Atopic Dermatitis, Malignancy and Collagen Disease

An increase in the occurrence of malignancy, severe collagen disease, and treatment-resistant and severe atopic dermatitis (AD) has been induced by free radicals which have increased in number as environmental pollutants, especially since 1970. Free radicals are mainly generated by nitrogen oxides (NOx), which are largely a product of petroleum combustion, and ultraviolet radiation, which has been enhanced by breaks in the earth's ozone layer caused by halogenated hydrocarbon gases. Treatment of these diseases in western medicine has used only chemotherapy or radiation which has a cytotoxic side effect that finally kills the human cells or corticoid therapy which also produces various and sometimes fatal side effects. On the other hand, non-main stream treatments such an biological medicine using natual plants and seeds have shown that although there are no side effects, their effectiveness is very limited. In this report, we have succeeded in developing effective natural products without side effects from natural materials; there is an abundance of low-or high-molecular weight compounds with antioxidant or cancer-cidal activity occurring in natural materials as repeating subunits of high-molecular weight inactive polymers. We developed an effective natural antioxidant by a unique treating procedure that includes heating with far infrared radiation (4-14 micro m wavelength) and brewing with the fungus Aspergillus oryzae to liberate the repeating units as active forms. The antioxidant named 'AOA (antioxidant analog)' is produced from wheat germ, rice bran, soybean, 'Hatomugi' (a kind of oriental wheat), wheat and sesame seed. We also obtained natural cancer-retardants BG-104, BG-103 and BWS, from the materials of Chinese herbs, mycelia and loquat. These natural cancer-retardants and antioxidant have shown dramatic effectiveness without any side effects in malignancy patients during progression and end stages and in severe collagen disease patients. The effectiveness exceeded that of cytotoxic chemotherapy, radiation or corticoid therapy in some subsets of the patients.