Interoceptive brain network mechanisms of mindfulness-based training in healthy adolescents
Author: Olga Tymofiyeva#1, Benjamin S Sipes#1, Tracy Luks1, Elissa J Hamlat2,3, Tara E Samson1, Thomas J Hoffmann4, David V Glidden4, Angela Jakary1, Yi Li1, Tiffany Ngan1, Eva Henje#5, Tony T Yang#2,3
Affiliation:
1 Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
2 Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA, United States.
3 Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
4 Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
5 Department of Clinical Science/Child- and Adolescent Psychiatry, Umeå University, Umeå, Sweden.
Conference/Journal: Front Psychol
Date published: 2024 Aug 13
Other:
Volume ID: 15 , Pages: 1410319 , Special Notes: doi: 10.3389/fpsyg.2024.1410319. , Word Count: 364
Introduction:
This study evaluated changes in the white matter of the brain and psychological health variables, resulting from a neuroscience-based mindfulness intervention, the Training for Awareness, Resilience, and Action (TARA), in a population of healthy adolescents.
Methods:
A total of 100 healthy adolescents (57 female, age ranges 14-18 years) were randomized into the 12-week TARA intervention or a waitlist-control group. All participants were imaged with diffusion MRI to quantify white matter connectivity between brain regions. Imaging occurred at baseline/randomization and after 12 weeks of baseline (pre- and post-intervention in the TARA group). We hypothesized that structural connectivity in the striatum and interoceptive networks would increase following the TARA intervention, and that, this increased connectivity would relate to psychological health metrics from the Strengths and Difficulties Questionnaire (SDQ) and the Insomnia Severity Index (ISI). The TARA intervention and all assessments, except for the MRIs, were fully remotely delivered using secure telehealth platforms and online electronic data capture systems.
Results:
The TARA intervention showed high consistency, tolerability, safety, recruitment, fidelity, adherence, and retention. After 12 weeks, the TARA group, but not controls, also demonstrated significantly improved sleep quality (p = 0.02), and changes in the right putamen node strength were related to this improved sleep quality (r = -0.42, p = 0.006). Similarly, the TARA group, but not controls, had significantly increased right insula node strength related to improved emotional well-being (r = -0.31, p = 0.04). Finally, we used the network-based statistics to identify a white matter interoception network that strengthened following TARA (p = 0.009).
Discussion:
These results suggest that the TARA mindfulness-based intervention in healthy adolescents is feasible and safe, and it may act to increase structural connectivity strength in interoceptive brain regions. Furthermore, these white matter changes are associated with improved adolescent sleep quality and emotional well-being. Our results suggest that TARA could be a promising fully remotely delivered intervention for improving psychological well-being in adolescents. As our findings suggest that TARA affects brain regions in healthy adolescents, which are also known to be altered during depression in adolescents, future studies will examine the effects of TARA on depressed adolescents.
Clinical trial registration:
https://clinicaltrials.gov/study/NCT04254796.
Keywords: MRI; adolescence; brain connectivity; interoception; mindfulness; mindfulness practices such as meditation.
PMID: 39193038 PMCID: PMC11348390 DOI: 10.3389/fpsyg.2024.1410319
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