Intervention of muscle-building and antifrailty exercise combined with Baduanjin for frailty of different functional levels: study protocol for a randomised controlled trial
Author: Shuaixuan Xu#1,2, Zhuyun Gong#3, Fang Wang#1,4, Mengyu Cao1, Jinwei Liu1,4, Chao Chen1,4, Nihui Zhang1,4, Jingwen Kang1, Chuang Xu1,4, Nan Peng5
Affiliation:
1 Department of Rehabilitation Medicine, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
2 Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan, China.
3 Department of Outpatient, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
4 Graduate School, Chinese PLA General Hospital, Beijing, China.
5 Department of Rehabilitation Medicine, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China pengnan301@163.com.
Conference/Journal: BMJ Open
Date published: 2023 Dec 14
Other:
Volume ID: 13 , Issue ID: 12 , Pages: e074827 , Special Notes: doi: 10.1136/bmjopen-2023-074827. , Word Count: 305
Introduction:
Frailty has been currently considered as a multidimensional concept, including physical, cognitive and social frailty. Frailty has also been associated with a range of adverse events, which might increase the risks of disability, falls, fractures, delirium and death. Increasing evidence has shown that multicomponent exercise training can improve physical and cognitive function, delay or reverse frailty. However, there is still a lack of exercise intervention programmes for the frail older adults in China. This trial aims to investigate the effects of the muscle-building and antifrailty exercise combined with Baduanjin on the physical function of frail older adults, as well as the effectiveness and safety of the intervention.
Methods and analysis:
This study is a prospective randomised controlled trial. A total of 192 patients, aged 70 years or older, who are diagnosed as prefrailty or frailty based on the Fried criteria will be included. Prior written and informed consent will be obtained from every subject. These subjects will be randomly assigned to the exercise intervention group (n=96) and the control group (n=96). The exercise intervention group will undergo different exercise programmes for different levels of physical function. They will perform the muscle-building and antifrailty exercise three times per week for 30-60 min for 24 weeks. The control group will implement health education on frailty and maintain the old lifestyle without any intervention.The primary outcomes include the change in frailty and functional capacity, assessed according to the Fried Scale and the Short Physical Performance Battery. Secondary outcomes include the changes in body composition, Activities of daily living, Mini-Mental State Examination, The Geriatric Depression Scale-15 and the haematological indicators.
Ethics statement:
The study has been approved by the Medical Ethics Committee of the PLA General Hospital (approval no.: S2022-600-02).
Trial registration number:
ChiCTR2300070535.
Keywords: GERIATRIC MEDICINE; Health Services for the Aged; Protocols & guidelines.
PMID: 38101837 DOI: 10.1136/bmjopen-2023-074827
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