Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review
Author: Matyas Jelinek1, Jolana Lipkova2, Kamil Duris3
Affiliation:
1 Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
2 Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
3 Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurosurgery, The University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: kduris@med.muni.cz.
Conference/Journal: Exp Neurol
Date published: 2023 Nov 30
Other:
Pages: 114628 , Special Notes: doi: 10.1016/j.expneurol.2023.114628. , Word Count: 104
Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.
Keywords: Inflammation; Stroke; Vagus nerve stimulation.
PMID: 38042360 DOI: 10.1016/j.expneurol.2023.114628
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