Mitochondria: A Potential Rejuvenation Tool against Aging

Author: Qian Hua Phua1,2, Shi Yan Ng1,3,4, Boon-Seng Soh1,2
1 Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.
2 Department of Biological Sciences, National University of Singapore, Singapore.
3 National University of Singapore, Yong Loo Lin School of Medicine (Department of Physiology), Singapore.
4 National Neuroscience Institute, Singapore.
Conference/Journal: Aging Dis
Date published: 2023 Oct 3
Other: Special Notes: doi: 10.14336/AD.2023.0712. , Word Count: 153

Aging is a complex physiological process encompassing both physical and cognitive decline over time. This intricate process is governed by a multitude of hallmarks and pathways, which collectively contribute to the emergence of numerous age-related diseases. In response to the remarkable increase in human life expectancy, there has been a substantial rise in research focusing on the development of anti-aging therapies and pharmacological interventions. Mitochondrial dysfunction, a critical factor in the aging process, significantly impacts overall cellular health. In this extensive review, we will explore the contemporary landscape of anti-aging strategies, placing particular emphasis on the promising potential of mitotherapy as a ground-breaking approach to counteract the aging process. Moreover, we will investigate the successful application of mitochondrial transplantation in both animal models and clinical trials, emphasizing its translational potential. Finally, we will discuss the inherent challenges and future possibilities of mitotherapy within the realm of aging research and intervention.

PMID: 37815912 DOI: 10.14336/AD.2023.0712