Whether mindfulness-guided therapy can be a new direction for the rehabilitation of patients with Parkinson's disease: a network meta-analysis of non-pharmacological alternative motor-/sensory-based interventions

Author: Shenglan He1, Wanyi Fang1, Jiaoyang Wu1, Hang Lv2, Jueyu Zhang1,3, Tunyi Wang1, Yingjie Huang1, Guangyao Li1, Min Li1
1 Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
2 The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, China.
3 Guangdong Second Traditional Chinese Medicine Hospital (Fifth Clinical Medical College of Guangzhou University of Chinese Medicine), Guangzhou, China.
Conference/Journal: Front Psychol
Date published: 2023 Sep 14
Other: Volume ID: 14 , Pages: 1162574 , Special Notes: doi: 10.3389/fpsyg.2023.1162574. , Word Count: 233

The treatment for Parkinson's disease (PD) consumes a lot of manpower and financial resources. Non-pharmacological alternative motor-/sensory-based interventions are optimized for the rehabilitation of PD patients. Mindfulness-based therapy shows ideal efficacy, but the diversity of the therapy brings difficulties to the selection of clinicians and patients.

Network meta-analysis in the Bayesian framework was used to evaluate the efficacy of non-pharmacological alternative motor-/sensory-based interventions in improving motor and non-motor symptoms in PD patients.

A total of 58 studies (2,227 patients) were included. Compared with the non-intervention group, qigong was associated with improved outcomes in the Timed Up and Go (TUG) test (mean difference (MD) -5.54, 95% confidence interval (CI) -8.28 to -2.77), and UPDRS-I (MD -15.50, 95% CI -19.93 to -7.63). Differences between non-pharmacological alternative motor-/sensory-based interventions were not significant for PDQ-39, UPDRS-I, or UPDRS-II; however, qigong was superior to dance (MD -3.91, 95% CI -6.90 to -0.95), Tai Chi (MD -3.54, 95% CI -6.53 to -0.69), acupuncture (MD -6.75, 95% CI -10.86 to -2.70), music (MD -3.91, 95% CI -7.49 to -0.48), and exercise (MD -3.91, 95% CI -6.49 to -1.33) in the TUG test.

This network meta-analysis supports mindfulness-based therapy (e.g., qigong, yoga, and Tai Chi) as a preferred non-pharmacological alternative motor-/sensory-based intervention for PD rehabilitation.

Systematic review registration:
https://inplasy.com/inplasy-2022-10-0109/, INPLASY2022100109.

Keywords: Parkinson’s disease; mindfulness-guided therapy; network meta-analysis; non-pharmacological interventions; qigong.

PMID: 37780170 PMCID: PMC10540073 DOI: 10.3389/fpsyg.2023.1162574