Distinct roles of telomerase activity in age-related chronic diseases: An update literature review
Author: Xiaodan Wang1, Hao Deng1, Jingyi Lin1, Kai Zhang1, Jingyu Ni1, Lan Li2, Guanwei Fan3
Affiliation:
1 Medical Experiment Center, Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 300381 Tianjin, China.
2 State Key Laboratory of Modern Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae for the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
3 Medical Experiment Center, Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 300381 Tianjin, China. Electronic address: guanwei.fan@tjutcm.edu.cn.
Conference/Journal: Biomed Pharmacother
Date published: 2023 Sep 20
Other:
Volume ID: 167 , Pages: 115553 , Special Notes: doi: 10.1016/j.biopha.2023.115553. , Word Count: 146
Although telomerase has low activity in somatic quiescent cells, it plays an significant roles in regenerative cells such as endothelial cells, hepatocytes, epithelial cells, and hemocytes. Telomerase activity and telomere length are critical factors in age-related chronic diseases as they are closely related to cell senescence. However, whether telomerase activity plays a key role in disease progression or whether the role of telomerase is unified among different diseases are unresolved. Considering that aging is the most important risk factor for neurodegenerative and metabolic diseases, this article will analyze the evidence, mechanism, and therapeutic potential of telomerase activity in several chronic disease, including type 2 diabetes, neurodegenerative diseases, atherosclerosis, heart failure and non-alcoholic fatty liver disease, in order to provide clues for the use of telomerase activity to target the treatment of age-related chronic diseases.
Keywords: Age-related degenerative diseases; Aging; Telomerase activity; Therapeutic prospect.
PMID: 37738798 DOI: 10.1016/j.biopha.2023.115553
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