Pulsed Electromagnetic Fields (PEMF)-Physiological Response and Its Potential in Trauma Treatment

Author: Jonas Flatscher1, Elizabeth Pavez Loriè1, Rainer Mittermayr2, Paul Meznik2, Paul Slezak1, Heinz Redl1, Cyrill Slezak1,3
1 Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, 1200 Vienna, Austria.
2 AUVA Trauma Center Vienna-Meidling, 1120 Vienna, Austria.
3 Department of Physics, Utah Valley University, Orem, UT 84058, USA.
Conference/Journal: Int J Mol Sci
Date published: 2023 Jul 8
Other: Volume ID: 24 , Issue ID: 14 , Pages: 11239 , Special Notes: doi: 10.3390/ijms241411239. , Word Count: 201

Environmental biophysical interactions are recognized to play an essential part in the human biological processes associated with trauma recovery. Many studies over several decades have furthered our understanding of the effects that Pulsed Electromagnetic Fields (PEMF) have on the human body, as well as on cellular and biophysical systems. These investigations have been driven by the observed positive clinical effects of this non-invasive treatment on patients, mainly in orthopedics. Unfortunately, the diversity of the various study setups, with regard to physical parameters, molecular and cellular response, and clinical outcomes, has made it difficult to interpret and evaluate commonalities, which could, in turn, lead to finding an underlying mechanistic understanding of this treatment modality. In this review, we give a birds-eye view of the vast landscape of studies that have been published on PEMF, presenting the reader with a scaffolded summary of relevant literature starting from categorical literature reviews down to individual studies for future research studies and clinical use. We also highlight discrepancies within the many diverse study setups to find common reporting parameters that can lead to a better universal understanding of PEMF effects.

Keywords: PEMF; biophysical forces; cellular signaling; clinical use; electromagnetic field; regeneration.

PMID: 37510998 PMCID: PMC10379303 DOI: 10.3390/ijms241411239