Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson's disease
Author: Júlio César Claudino Dos Santos1, Leandro Freitas Oliveira2, Felipe Micelli Noleto3, Camilla Teixeira Pinheiro Gusmão4, Gerly Anne de Castro Brito5, Glauce Socorro de Barros Viana6
Affiliation:
1 Christus University Center - UNICHRISTUS, Fortaleza; Postgraduate Program in Morphofunctional Sciences, Federal University of Ceará - UFC, Fortaleza, CE, Brazil.
2 Universidade Católica de Brasília - UCB, Brasília, DF, Brasil.
3 Christus University Center - UNICHRISTUS, Fortaleza, CE, Brazil.
4 Postgraduate Program in Physiology and Pharmacology Department of the Federal University of Ceará - UFC, Fortaleza, CE, Brazil.
5 Postgraduate Program in Morphofunctional Sciences, Federal University of Ceará - UFC; Physiology and Pharmacology Department of the Federal University of Ceará - UFC, Fortaleza, CE, Brazil, Fortaleza.
6 Physiology and Pharmacology Department of the Federal University of Ceará - UFC, Fortaleza, CE, Brazil.
Conference/Journal: Neural Regen Res
Date published: 2023 Dec 1
Other:
Volume ID: 18 , Issue ID: 12 , Pages: 2611-2614 , Special Notes: doi: 10.4103/1673-5374.373673. , Word Count: 148
This critical review of the literature shows that there is a close link between the microbiome, the gut, and the brain in Parkinson's disease. The vagus nerve, the main component of the parasympathetic nervous system, is involved in the regulation of immune response, digestion, heart rate, and control of mood. It can detect microbiota metabolites through its afferents, transferring this gut information to the central nervous system. Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression, as well as treatment responses. These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease. More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit.
Keywords: Parkinson’s disease; alpha-synuclein; enteric microbiota; gastrointestinal tract; vagus nerve.
PMID: 37449597 DOI: 10.4103/1673-5374.373673
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