Author: Maria Fernanda Naufel1, Giselle de Martin Truzzi2, Caroline Marcantonio Ferreira3, Fernando Morgadinho Santos Coelho2,4
1 Universidade Federal de São Paulo, Departamento de Fisiologia, São Paulo SP, Brazil.
2 Universidade Federal de São Paulo, Departamento de Psicobiologia, São Paulo SP, Brazil.
3 Universidade Federal de São Paulo, Departamento de Ciências Farmacêuticas, São Paulo SP, Brazil.
4 Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
Conference/Journal: Arq Neuropsiquiatr
Date published: 2023 Jul 4
Other: Special Notes: doi: 10.1055/s-0043-1767818. , Word Count: 199
The human gut microbiota is a complex ecosystem made of trillions of microorganisms. The composition can be affected by diet, metabolism, age, geography, stress, seasons, temperature, sleep, and medications. The increasing evidence about the existence of a close and bi-directional correlation between the gut microbiota and the brain indicates that intestinal imbalance may play a vital role in the development, function, and disorders of the central nervous system. The mechanisms of interaction between the gut-microbiota on neuronal activity are widely discussed. Several potential pathways are involved with the brain-gut-microbiota axis, including the vagus nerve, endocrine, immune, and biochemical pathways. Gut dysbiosis has been linked to neurological disorders in different ways that involve activation of the hypothalamic-pituitary-adrenal axis, imbalance in neurotransmitter release, systemic inflammation, and increase in the permeability of the intestinal and the blood-brain barrier. Mental and neurological diseases have become more prevalent during the coronavirus disease 2019pandemic and are an essential issue in public health globally. Understanding the importance of diagnosing, preventing, and treating dysbiosis is critical because gut microbial imbalance is a significant risk factor for these disorders. This review summarizes evidence demonstrating the influence of gut dysbiosis on mental and neurological disorders.
PMID: 37402401 DOI: 10.1055/s-0043-1767818