Exercise Rehabilitation and Chronic Respiratory Diseases: Effects, Mechanisms, and Therapeutic Benefits

Author: Ting Xiong1, Xinyue Bai1, Xingyi Wei1, Lezheng Wang1, Fei Li2, Hui Shi3, Yue Shi2
1 School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, People's Republic of China.
2 School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, People's Republic of China.
3 Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Conference/Journal: Int J Chron Obstruct Pulmon Dis
Date published: 2023 Jun 19
Other: Volume ID: 18 , Pages: 1251-1266 , Special Notes: doi: 10.2147/COPD.S408325. , Word Count: 188

Chronic respiratory diseases (CRD), is a group of disorders, primarily chronic obstructive pulmonary disease and asthma, which are characterized by high prevalence and disability, recurrent acute exacerbations, and multiple comorbidities, resulting in exercise limitations and reduced health-related quality of life. Exercise training, an important tool in pulmonary rehabilitation, reduces adverse symptoms in patients by relieving respiratory limitations, increasing gas exchange, increasing central and peripheral hemodynamic forces, and enhancing skeletal muscle function. Aerobic, resistance, and high-intensity intermittent exercises, and other emerging forms such as aquatic exercise and Tai Chi effectively improve exercise capacity, physical fitness, and pulmonary function in patients with CRD. The underlying mechanisms include enhancement of the body's immune response, better control of the inflammatory response, and acceleration of the interaction between the vagus and sympathetic nerves to improve gas exchange. Here, we reviewed the new evidence of benefits and mechanisms of exercise intervention in the pulmonary rehabilitation of patients with chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis, interstitial lung disease, and lung cancer.

Keywords: asthma; bronchiectasis; chronic obstructive pulmonary disease; chronic respiratory disease; exercise training; interstitial lung disease; lung cancer.

PMID: 37362621 PMCID: PMC10289097 DOI: 10.2147/COPD.S408325