Exercise As a Therapy to Maintain Telomere Function and Prevent Cellular Senescence

Author: Jeongjin J Kim1, Alexander Ahn, Jeffrey Ying, Evan Hickman, Andrew T Ludlow
1 School of Kinesiology, University of Michigan, Ann Arbor, MI, 48109.
Conference/Journal: Exerc Sport Sci Rev
Date published: 2023 Jun 8
Other: Special Notes: doi: 10.1249/JES.0000000000000324. , Word Count: 55

Exercise transiently impacts the expression, regulation, and activity of TERT/telomerase to maintain telomeres and protect the genome from insults. By protecting the telomeres (chromosome ends) and the genome, telomerase promotes cellular survival and prevents cellular senescence. By increasing cellular resiliency, via the actions of telomerase and TERT, exercise promotes healthy aging.

PMID: 37288975 DOI: 10.1249/JES.0000000000000324