Author: Jon O Lundberg1, Eddie Weitzberg2
1 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address: email@example.com.
2 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address: firstname.lastname@example.org.
Date published: 2022 Aug 4
Other: Volume ID: 185 , Issue ID: 16 , Pages: 2853-2878 , Special Notes: doi: 10.1016/j.cell.2022.06.010. , Word Count: 126
The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is complex, and novel insights into the control of NO biosynthesis and mechanisms of signal transduction are continuously emerging. NO is a key regulator of cardiovascular function, metabolism, neurotransmission, immunity, and more, and aberrant NO signaling is a central feature of many major disorders including cardiovascular disease, diabetes, and cancer. Here, we discuss the basics of NO biology emphasizing recent advances in the field including novel means of increasing NO bioactivity with therapeutic and nutritional implications.
Keywords: S-nitrosothiol; blood pressure; cancer; cardiovascular disease; nitrate; nitrite.
PMID: 35931019 DOI: 10.1016/j.cell.2022.06.010