Author: Pradeep S Rajendran1, Joseph Hadaya2, Sahib S Khalsa3, Chuyue Yu4, Rui Chang4, Kalyanam Shivkumar5
Affiliation:
1 Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: prajendran@partners.org.
2 University of California, Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; UCLA Molecular, Cellular, and Integrative Physiology Program, Los Angeles, CA, USA.
3 Laureate Institute for Brain Research, Tulsa, Ok, USA; Oxley College of Health Sciences, University of Tulsa, Tulsa, Ok, USA.
4 Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
5 University of California, Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; UCLA Molecular, Cellular, and Integrative Physiology Program, Los Angeles, CA, USA. Electronic address: kshivkumar@mednet.ucla.edu.
Conference/Journal: Semin Cell Dev Biol
Date published: 2023 Jan 12
Other:
Special Notes: doi: 10.1016/j.semcdb.2023.01.001. , Word Count: 111
The parasympathetic nervous system via the vagus nerve exerts profound influence over the heart. Together with the sympathetic nervous system, the parasympathetic nervous system is responsible for fine-tuned regulation of all aspects of cardiovascular function, including heart rate, rhythm, contractility, and blood pressure. In this review, we highlight vagal efferent and afferent innervation of the heart, with a focus on insights from comparative biology and advances in understanding the molecular and genetic diversity of vagal neurons, as well as interoception, parasympathetic dysfunction in heart disease, and the therapeutic potential of targeting the parasympathetic nervous system in cardiovascular disease.
Keywords: Cardiovascular disease; Cardiovascular physiology; Interoception; Neuromodulation; Vagus nerve.
PMID: 36641366 DOI: 10.1016/j.semcdb.2023.01.001
