Remotely monitored Baduanjin exercise in moderate-to-severe chronic obstructive pulmonary disease patients (BROCADE): A study protocol

Author: Shuanglan Xu1, Zhifei Yin2, Zi Chen1, Dandan Zhang1,3, Sheng Ye1,4, Ping Zhou5, Aiping Chen6, Di Wu2, Weihua Liu1, Liuchao Zhang1, Liquan Guo7, Guangxu Xu2, Linfu Zhou1,8
1 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
2 Department of Geriatric Rehabilitation Medicine, Centre of Rehabilitation Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
3 Department of Respiratory Medicine, Geriatric Hospital of Nanjing Medical University, Nanjing, China.
4 Department of Respiratory Medicine, BenQ Hospital of Nanjing Medical University, Nanjing, China.
5 School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China.
6 Department of Radiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
7 Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
8 Institute of Integrative Medicine, Nanjing Medical University, Nanjing, China.
Conference/Journal: Medicine (Baltimore)
Date published: 2022 Dec 30
Other: Volume ID: 101 , Issue ID: 52 , Pages: e32079 , Special Notes: doi: 10.1097/MD.0000000000032079. , Word Count: 268

Baduanjin is a traditional Chinese exercise regimen used to treat various chronic illnesses and is associated with both psychological and physical benefits. However, its benefits for patients suffering from chronic obstructive pulmonary disease (COPD) are unclear. This study aims to assess the efficacy, safety, and underlying mechanisms of Baduanjin exercise in patients with moderate-to-severe COPD (BROCADE) by remote monitoring.

This study protocol describes a multicenter, open-label, prospective randomized computed tomography. A total of 150 individuals who meet the inclusion criteria after the screening and consent processes will take part in the study. All participants will be provided routine medication and lifestyle interventions. They will be randomly assigned to a control group, a classical pulmonary rehabilitation group, or a Baduanjin group, which will undergo remotely monitored Baduanjin exercises for a cumulative duration of 1 hour per day, three times per week for 12 weeks. The participants will be followed for 24 weeks. The primary outcomes will be a 6-minutes walking distance and St. George's Respiratory Questionnaire index. The secondary outcomes will be lung function, cross-sectional area of the pectoralis major and subcutaneous fat, modified Medical Research Council score, COPD assessment test questionnaire results, extremity muscle strength, and quality of life. Any adverse events that may occur will be monitored and recorded.

This study is ongoing and will be submitted to a peer-reviewed journal for publication once completed.

A novel neutrophil-related inflammatory mechanism will potentially be identified. In addition, the study results will provide a safe, effective, simple and operational Baduanjin exercise protocol for moderate-to-severe COPD patients aimed at improving prognosis and quality of life.

PMID: 36596062 PMCID: PMC9803505 DOI: 10.1097/MD.0000000000032079