Author: Shengnan Yue#1, Jing Zhang#1, Jiaxin Li1,2, Yanwei Hao1,2, Shaofeng Wang2, Tianyu Liu3, Wen Zhong1, Chongli Chen1, Fei Wang1, Bin Li4
1 Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan, China.
2 School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
3 School of Physical Education and Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China.
4 Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan, China. email@example.com.
Conference/Journal: BMC Complement Med Ther
Date published: 2022 Nov 18
Other: Volume ID: 22 , Issue ID: 1 , Pages: 298 , Special Notes: doi: 10.1186/s12906-022-03778-9. , Word Count: 335
Accompanied by the decline of physiological functions, the decrease of physical activity, and comorbidities, older adults are susceptible to sarcopenia because of accelerated loss of muscle mass. Resistance training is recommended by different clinical practice guidelines. However, most older adults have difficulty in taking recommended high-load resistance training programs, and there are limited exercise options form them. Baduanjin, a traditional Chinese mind-body exercise with relatively low intensity and simple movements, has the potential benefits of improving physical functions and may be feasible in treating sarcopenia and preventing its adverse health outcomes in older patients. With the emergence of the concept of gut-muscle axis, this study aims to determine the efficacy of Baduanjin exercise on Chinese older adults with sarcopenia and explore its underlying mechanism.
This is a 24-week, assessor-blinded, randomized controlled trial. Individuals aged 60 to 84 years old will be screened for sarcopenia. 90 participants with sarcopenia will be enrolled and randomly assigned (1:1) into the Baduanjin exercise or resistance training group, and 20 participants without sarcopenia will be set as the non-sarcopenia control group. The primary outcome is the scores of Short Physical Performance Battery. The secondary outcomes are body composition, handgrip strength, walking speed, global cognitive function, and incidence of falls. These outcomes will be assessed at baseline, the 12th week and the 24th week. While stool samples from participants will be collected at baseline and the 24th week for analyzing the abundance of gut microbiome. Data will be analyzed in an intention-to-treat protocol.
The results of this study will determine whether Baduanjin exercise can be an alternative non-pharmacological approach for older adults with sarcopenia. If they can show positive significance, it will promote Baduanjin exercise in clinical practice among these patients and inform further research involving exercise interventions on the optimal types, timing, and intensity to ameliorate sarcopenia for elderly people.
Chinese Clinical Trial Registry; Registration number: ChiCTR2100051871; Prospectively registered on October 8th, 2021.
Keywords: Baduanjin; Older adults; Physical function; Randomized controlled trial; Sarcopenia.
PMID: 36401254 PMCID: PMC9673889 DOI: 10.1186/s12906-022-03778-9