Author: Vera Korenblik1, Marlies E Brouwer2, Aniko Korosi3, Damiaan Denys2, Claudi L H Bockting2, Stanley Brul4, Anja Lok5
Affiliation:
1 Department of Psychiatry, Amsterdam University Medical Centers, Location AMC, Meibergdreef 5, 1105, AZ, Amsterdam, the Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands; Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands.
2 Department of Psychiatry, Amsterdam University Medical Centers, Location AMC, Meibergdreef 5, 1105, AZ, Amsterdam, the Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands.
3 Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands.
4 Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands; Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands.
5 Department of Psychiatry, Amsterdam University Medical Centers, Location AMC, Meibergdreef 5, 1105, AZ, Amsterdam, the Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: a.lok@amsterdamumc.nl.
Conference/Journal: Neuropharmacology
Date published: 2022 Nov 2
Other:
Special Notes: doi: 10.1016/j.neuropharm.2022.109318. , Word Count: 270
The microbiota-gut-brain axis (MGBA) refers to the bidirectional communication between the brain and the gut microbiota and recent studies have linked the MGBA to health and disease. Research has so far investigated this axis mainly from microbiota to brain but less is known about the other direction. One approach to examine the MGBA from brain to microbiota is through understanding if and how neuromodulation might impact microbiota. Neuromodulation encompasses a wide range of stimulation techniques and is used to treat neurological, psychiatric and metabolic disorders, like Parkinson's Disease, depression and obesity. Here, we performed a systematic review to investigate whether neuromodulation is associated with subsequent changes in the gut microbiota. Searches in PsycINFO and MEDLINE were performed up to March 2022. Included studies needed to be clinical or preclinical studies comparing the effects of deep brain stimulation, electroconvulsive therapy, repetitive transcranial magnetic stimulation, transcranial direct current stimulation or vagal nerve stimulation on the gut microbiota before and after treatment or between active and control groups. Seven studies were identified. Neuromodulation was associated with changes in relative bacterial abundances, but not with (changes in) α-diversity or β-diversity. Summarizing, currently reported findings suggest that neuromodulation interventions are associated with moderate changes in the gut microbiome. However, findings remain inconclusive due to the limited number and varying quality of included studies, as well as the large heterogeneity between studies. More research is required to more conclusively establish whether, and if so, via which mechanism(s) of action neuromodulation interventions might influence the gut microbiota.
Keywords: Deep brain stimulation; Gut microbiota; Microbiota-gut-brain axis; Neuromodulation; Repetitive transcranial magnetic stimulation; Vagal nerve stimulation.
PMID: 36334762 DOI: 10.1016/j.neuropharm.2022.109318
