Effects of intermediate frequency electromagnetic fields: a review of animal studies

Author: Hae-June Lee1, Hee Jin2, Young Hwan Ahn3, Nam Kim4, Jeong Ki Pack5, Hyung-Do Choi6, Yun-Sil Lee2
1 Division of Basic Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, Seoul 03760, Korea.
2 School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
3 Department of Neurosurgery, Ajou University School of Medicine, Suwon, 16499, Korea.
4 School of Information and Communication Engineering, Chungbuk National University, Cheongju, Chungbuk, 28644, Korea.
5 Department of Radio and Information Communications Engineering, Chungnam National University, Daejon, 34134, Korea.
6 Radio & Satellite Research Division, Electronics and Telecommunications Research Institute, Daejeon 34129, Korea.
Conference/Journal: Int J Radiat Biol
Date published: 2022 Jun 27
Other: Special Notes: doi: 10.1080/09553002.2022.2094016. , Word Count: 231

Many novel devices such as induction cookers or wireless power transfer produce electromagnetic fields (EMFs) in the intermediate frequency (IF) range (300 Hz to 10 MHz) and it is very meaningful for summarizing the bioeffects of IF-EMF research, particularly animal studies. This review takes into account experimental studies that used murine models to study the health effects of exposure to IF-EMF. The analyses included here use data available in the literature published from January 1988 to August 2021 including the animal studies about general adverse effects, tumorigenic effects, and effects on developmental stages. The studies that linked IF-EMF exposure during pregnancy or neonatal stage to behavioral and cognition changes were included. Additionally, this review also covers the effects of IF-EMF on gene expression patterns in the brain, behavior patterns associated with learning and memory, and immune function.

Although most studies have suggested that IF-EMF is harmless, some adverse effects have been reported after exposure at developmental stages and prolonged exposure. Compared to extremely low frequency (ELF) or radiofrequency (RF) EMF bands, studies on health effects with more diverse perspectives of IF-EMF have not been conducted. Therefore, performing more research should be necessary using the latest biomedical tools. From this point of view, a comprehensive review of IF-EMF studies, particularly animal studies, will provide a valuable basis for further risk analysis in humans.

Keywords: Health effects; IF-EMF exposure; Murine models; Published literature.

PMID: 35758938 DOI: 10.1080/09553002.2022.2094016