Effect of a 16-Session Qigong Program in Non-Hodgkin Lymphoma Survivors: A Randomized Clinical Trial

Author: Keyla Vargas-Román1,2, Emilia I De la Fuente-Solana3, Jonathan Cortés-Martín1, Juan Carlos Sánchez-García1,4, Christian J González-Vargas5, Lourdes Díaz-Rodríguez1,4
1 Research Group CTS1068, Andalusia Research Plan, Junta de Andalucía, 18014 Granada, Spain.
2 Spanish Education Ministry Program FPU16/01437, Methodology of Behavioral Sciences Department, Faculty of Psychology, University of Granada, 18071 Granada, Spain.
3 Methodology of Behavioral Sciences Department, Faculty of Psychology, University of Granada, 18071 Granada, Spain.
4 Department of Nursing, Faculty of Health Sciences, University of Granada, 18016 Granada, Spain.
5 Fulton Schools of Engineering Department, Faculty of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ 85281, USA.
Conference/Journal: J Clin Med
Date published: 2022 Jun 14
Other: Volume ID: 11 , Issue ID: 12 , Pages: 3421 , Special Notes: doi: 10.3390/jcm11123421. , Word Count: 246

The treatment associated with non-Hodgkin lymphoma patients may cause adverse effects on their physical and psychological condition. The aim of this study is to detect the response to an eight-week, 16-session, 60-min presential Qigong program in anxiety, depression and vagal nerve activity alongside a control group.

A randomized controlled clinical trial was managed. Randomization was carried out by generating a numerical sequence of three cycles through the software EPIDAT 4.1. Numbers were placed in sealed opaque envelopes for assignment to the different groups.

Anxiety levels were substantially decreased in the experimental group, with a large effect size (F = 30.38, p < 0.00). Depression levels had an improvement in the experimental group in contrast to the control group, reaching statistical significance (F = 19.19, p < 0.00). Heart Rate Variability unveiled significant results in terms of between-group differences, with a large effect size in the HRV Index (F = 15.80, p < 0.00), SDNN (F = 8.82, p < 0.00), and RMSSD (F = 6.72, p < 0.01) in the time domain, and a medium effect size in the HF (F = 9.78, p < 0.003), LF (F = 9.78, p < 0.00), and LF/HF Ratio (F = 18.44, p < 0.00) in the frequency domain, which were all bettered in the experimental group, after the Qigong program.

Qigong therapy can be an effective therapeutic activity in consonance with traditional medicine to improve psychological health and autonomic nervous system balance in non-Hodgkin lymphoma survivors.

Keywords: HRV; anxiety; autonomic nervous system; depression; lymphoma cancer; non-Hodgkin lymphoma.

PMID: 35743490 DOI: 10.3390/jcm11123421