Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage
Author: Yu-Hang Jiang1, Jia-Kai He1, Ran Li1, Ze-Hao Chen1, Bao-Hui Jia2
Affiliation:
1 Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
2 Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. myrroossee@aliyun.com.
Conference/Journal: Chin J Integr Med
Date published: 2022 Mar 1
Other:
Volume ID: 28 , Issue ID: 3 , Pages: 272-280 , Special Notes: doi: 10.1007/s11655-022-3511-6. , Word Count: 150
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80% of all dementias. The pathogenesis of AD is complicated and enigmatic thus far. The mitochondrial cascade hypothesis assumes that mitochondrial damage may mediate, drive, or contribute to a variety of AD pathologies and may be the main factor in late-onset AD. Currently, there are no widely recognized drugs able to attenuate mitochondrial damage in AD. Notably, increasing evidence supports the efficacy of acupuncture for improving the mitochondrial structure and protecting mitochondrial functions in AD. This review reports the mechanisms by which acupuncture regulates mitochondrial dynamics, energy metabolism, calcium homeostasis and apoptosis. In conclusion, these findings suggest that AD mitochondrial dysfunction represents a reasonable therapeutic target and acupuncture could play a significant role in preventing and treating AD.
Keywords: Alzheimer’s disease; acupuncture; mitochondrial damage; review.
PMID: 35230607 DOI: 10.1007/s11655-022-3511-6
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