Emerging rejuvenation strategies-Reducing the biological age
Author: Bohan Zhang1, Alexandre Trapp1, Csaba Kerepesi1, Vadim N Gladyshev1
Affiliation:
1 Division of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Conference/Journal: Aging Cell
Date published: 2021 Dec 31
Other:
Special Notes: doi: 10.1111/acel.13538. , Word Count: 108
Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies from other longevity interventions, such as those that slow down aging, is challenging, and these anti-aging strategies are often referred to interchangeably. We suggest that the prerequisite for a rejuvenation intervention is a robust, sustained, and systemic reduction in biological age, which can be assessed by biomarkers of aging, such as epigenetic clocks. We discuss known and putative rejuvenation interventions and comparatively analyze them to explore underlying mechanisms.
Keywords: aging; biomarkers; epigenetic clocks; rejuvenation.
PMID: 34972247 DOI: 10.1111/acel.13538
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