ACUTE TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) IMPROVES VENTILATORY VARIABILITY AND AUTONOMIC MODULATION IN RESISTANT HYPERTENSIVE PATIENTS
Author: Gabriela Ministro1, Javier B Castaño1, Catarina A Barboza1, Eliezer G Moura1, Silvia E Ferreira-Melo2, Cristiano T Mostarda3, André Fattori4, Heitor Moreno-Junior2, Bruno Rodrigues5
Affiliation:
1 Laboratory of Cardiovascular Investigation & Exercise, School of Physical Education, University of Campinas (UNICAMP), Campinas, SP, Brazil.
2 Laboratory of Cardiovascular Pharmacology & Hypertension, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
3 Federal University of Maranhão, São Luís, MA, Brazil.
4 Department of Clinical Medicine, University of Campinas (UNICAMP), Campinas, SP, Brazil.
5 Laboratory of Cardiovascular Investigation & Exercise, School of Physical Education, University of Campinas (UNICAMP), Campinas, SP, Brazil; Laboratory of Cardiovascular Pharmacology & Hypertension, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: prof.brodrigues@gmail.com.
Conference/Journal: Respir Physiol Neurobiol
Date published: 2021 Dec 13
Other:
Volume ID: 297 , Pages: 103830 , Special Notes: doi: 10.1016/j.resp.2021.103830. , Word Count: 235
Here, we assessed the impact of one session of transcranial direct current stimulation (tDCS) or SHAM (20 min, each) on ventilatory responses to cardiopulmonary exercise test, central and peripheral blood pressure (BP), and autonomic modulation in resistant hypertensive (RHT) patients. RHT subjects (n = 13) were randomly submitted to SHAM and tDCS crossing sessions (1 week of "washout"). Patients and a technician who set the tDCS/Sham room up were both blind. After brain stimulation, patients were submitted to a cardiopulmonary exercise test to evaluate ventilatory and cardiovascular response to exercise. Hemodynamic (Finometer®, Beatscope), and autonomic variables were measured at baseline (before tDCS/Sham) and after incremental exercise. RESULTS: Our study shows that tDCS condition improved heart rate recovery, VO2 peak, and vagal modulation (after cardiopulmonary exercise test); attenuated the ventilatory variability response, central and peripheral blood pressure well as sympathetic modulation (after cardiopulmonary exercise test) in comparison with SHAM. These data suggest that acute tDCS sessions prevented oscillatory ventilation behavior during the cardiopulmonary exercise test and mitigated the increase of systolic blood pressure in RHT patients. After the exercise test, tDCS promotes better vagal reentry and improved autonomic modulation, possibly reducing central blood pressure and aortic augmentation index compared to SHAM. Brazilian Registry of Clinical Trials (ReBEC): https://ensaiosclinicos.gov.br/rg/RBR-8n7c9p.
Keywords: Autonomic modulation; Blood pressure; Cardiopulmonary exercise test; Exercise oscillatory ventilation; Resistant hypertension; Transcranial direct current stimulation (tDCS).
PMID: 34915178 DOI: 10.1016/j.resp.2021.103830
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