Efficacy of Whole-Body Vibration Training on Brain-Derived Neurotrophic Factor, Clinical and Functional Outcomes, and Quality of Life in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial

Author: Vanessa G C Ribeiro1,2,3, Ana C R Lacerda1,2,3,4,5, Jousielle M Santos1,2,3,4, Ana C Coelho-Oliveira1,4,6, Sueli F Fonseca1,2, Ana C N Prates1,3,4, Jurandir Flor1,3, Bruna C C Garcia1,2, Rosalina Tossige-Gomes1,2,3, Hércules R Leite1,2,3,7, José S C Fernandes8, Arthur N Arrieiro1,2,5, Alessandro Sartorio9, Borja Sañudo10, Danubia C Sá-Caputo6, Mário Bernardo-Filho6, Pedro H S Figueiredo1,2,3,4, Henrique S Costa1,3,4, Vanessa P Lima1,3,4, Renato F Cardoso1,4,5, Alessandra C Bastone1,3,4, Luana A Soares1,3, Vanessa A Mendonça1,2,3,4,5, Redha Taiar11
1 Integrated Center for Research and Post-Graduate Studies in Health (CIPq), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.
2 Multicentric Postgraduate Program in Physiological Sciences (PPGMCF), Brazilian Society of Physiology, Diamantina, MG, Brazil.
3 Physiotherapy Department, Faculty of Biological Sciences and Health, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil.
4 Postgraduate Program in Functional Performance and Rehabilitation (PPGReab), Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil.
5 Postgraduate Program in Health Sciences (PPGCS), Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil.
6 Mechanical Vibration Laboratory and Integrative Practices (LAVIMPI), Biophysics and Biometrics Department, Institute of Biology Roberto Alcântara Gomes and Piquet Carneiro Polyclinic, Rio de Janeiro State University, Rio de Janeiro, Brazil.
7 Postgraduate Program in Rehabilitation Sciences (PPGCR), School of Physical Education Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
8 Faculty of Agrarian Sciences, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil.
9 Istituto Auxologico Italiano, Division of Metabolic Diseases and Auxology & Experimental Laboratory for Auxo-endocrinological Research, Verbania, Italy.
10 Department of Physical Education and Sport, University of Seville, Seville 41013, Spain.
11 MATériaux et Ingénierie Mécanique (MATIM), Université de Reims Champagne-Ardenne, Reims, France.

Conference/Journal: J Healthc Eng
Date published: 2021 Nov 30
Other: Volume ID: 2021 , Pages: 7593802 , Special Notes: doi: 10.1155/2021/7593802. , Word Count: 216

This study aimed to investigate the efficacy of whole-body vibration training (WBVT) on blood brain-derived neurotrophic factor (BDNF) levels and determine the clinical and functional outcomes in patients with fibromyalgia syndrome (FMS). Thirty-two women with FMS were randomized into an intervention group (IG), receiving 6 weeks of WBVT, or a control group (CG) with no intervention. The outcomes at the baseline and follow-up in both groups included blood BDNF levels, sit-to-stand test (STS), 6-minute walk test (6MWT), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and visual analogue scale (VAS). WBVT resulted in a group-by-time interaction effect. Thus, after the intervention time, the IG had increased blood BDNF levels (p=0.045), a higher number of repetitions on the STS test (p=0.011), and increased walking distance on the 6MWT (p=0.010), compared to CG. Moreover, there was a reduction in the scores of the FIQ (p=0.001), the PSQI (p=0.001), the BDI (p=0.017), and pain assessed using VAS (p=0.008) in IG. The results demonstrate that WBVT promotes an increase in blood BDNF levels, with concomitant improvement in lower limb muscle strength, aerobic capacity, clinical symptoms, and quality of life in women with FMS. This trial is registered with Brazilian Clinical Trials Registry (REBEC; RBR-38nbbx) (https://ensaiosclinicos.gov.br/rg/RBR-38nbbx).

PMID: 34900203 PMCID: PMC8654532 DOI: 10.1155/2021/7593802