Mitochondria: in sickness and in health

Author: Jodi Nunnari1, Anu Suomalainen
1 Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA.
Conference/Journal: Cell
Date published: 2012 Mar 16
Other: Volume ID: 148 , Issue ID: 6 , Pages: 1145-59 , Special Notes: doi: 10.1016/j.cell.2012.02.035. , Word Count: 105

Mitochondria perform diverse yet interconnected functions, producing ATP and many biosynthetic intermediates while also contributing to cellular stress responses such as autophagy and apoptosis. Mitochondria form a dynamic, interconnected network that is intimately integrated with other cellular compartments. In addition, mitochondrial functions extend beyond the boundaries of the cell and influence an organism's physiology by regulating communication between cells and tissues. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease.

PMID: 22424226 PMCID: PMC5381524 DOI: 10.1016/j.cell.2012.02.035