Author: Wei Jiang1,2, Shaojun Liao3, Xiankun Chen2,4,5, Cecilia Stålsby Lundborg4, Gaetano Marrone4, Zehuai Wen5,6, Weihui Lu1,2
1 Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
2 The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
3 Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
4 Health Systems and Policy, Department of Global Public Health, Karolinska Institutet, Stockholm 17177, Sweden.
5 Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
6 National Centre for Design Measurement and Evaluation in Clinical Research, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Conference/Journal: Evid Based Complement Alternat Med
Date published: 2021 Jun 24
Other: Volume ID: 2021 , Pages: 5585239 , Special Notes: doi: 10.1155/2021/5585239. , Word Count: 226
Depression is a debilitating comorbidity of heart failure (HF) that needs assessment and management. Along with mind-body exercise to deal with HF with depression, the use of TaiChi and/or Qigong practices (TQPs) has increased. Therefore, this systematic review assesses the effects of TQPs on depression among patients with HF.
Randomized controlled trials (RCTs) that examined the effect of TQPs on depression in patients with HF were searched by five databases (PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, CINAHL, and China National Knowledge Infrastructure (CNKI)). With standardized mean difference (SMD) and 95% confidence intervals (95% CI), random-effects meta-analyses of the effect of TQPs on depressive symptoms were performed.
Of eight included RCTs, seven (481 patients) provided data for the meta-analysis. The pooling revealed that TQPs contribute to depression remission in HF (SMD -0.66; 95% CI -0.98 to -0.33, P < 0.0001; I 2 = 64%). Its antidepressive effect was not influenced by intervention duration or exercise setting, but rather by ejection fraction subtype, depressive severity, and depression instruments. The beneficial effects were preserved when the study with the largest effect was removed.
This study suggests that TQPs might be a good strategy for alleviating depressive symptoms in patients with HF. And rigorous-design RCTs, which focus on the identified research gaps, are needed to further establish the therapeutic effects of TQPs for depression in HF.
PMID: 34326885 PMCID: PMC8302391 DOI: 10.1155/2021/5585239