The role of nucleus of the solitary tract GLP1 and PrRP neurons in stress: anatomy, physiology, and cellular interactions

Author: Marie K Holt1, Linda Rinaman2
1 Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
2 Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, USA.
Conference/Journal: Br J Pharmacol
Date published: 2021 May 29
Other: Special Notes: doi: 10.1111/bph.15576. , Word Count: 151

Neuroendocrine, behavioural, and autonomic responses to stressful stimuli are orchestrated by complex neural circuits. The caudal nucleus of the solitary tract (cNTS) in the dorsomedial hindbrain is uniquely positioned to integrate signals of both interoceptive and psychogenic stress. Within the cNTS, glucagon-like peptide-1 (GLP1) and prolactin-releasing peptide (PrRP) neurons play crucial roles in organising neural responses to a broad range of stressors. In this review we discuss the anatomical and functional overlap between PrRP and GLP1 neurons. We outline their co-activation in response to stressful stimuli and their importance as mediators of behavioural and physiological stress responses. Finally, we review evidence that PrRP neurons are downstream of GLP1 neurons and outline unexplored areas of the research field. Based on the current state-of-knowledge, PrRP and GLP1 neurons may be compelling targets in the treatment of stress-related disorders.

Keywords: Gcg; HPA axis; NTS; Prlh; glucagon-like peptide-1; preproglucagon; prolactin-releasing peptide; stress.

PMID: 34050926 DOI: 10.1111/bph.15576