Mindfulness-based interventions for breast cancer patients in China across outcome domains: a systematic review and meta-analysis of the Chinese literature
Author: Shijie Jing1, Anao Zhang2, Yuying Chen3, Changyi Shen4, Jennifer Currin-McCulloch5, Chenfang Zhu6
Affiliation:
1 East China University of Political Science and Law, Room B112, Yangyongman Building, No.555, Longyuan Road, Songjiang District, Shanghai, 201620, China. jingshijie@ecupl.edu.cn.
2 University of Michigan, Ann Arbor, MI, USA.
3 East China University of Political Science and Law, Room B112, Yangyongman Building, No.555, Longyuan Road, Songjiang District, Shanghai, 201620, China.
4 Shanghai Mental Health Center, Shanghai, China.
5 Colorado State University, Fort Collins, CO, USA.
6 Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine, Shanghai, China.
Conference/Journal: Support Care Cancer
Date published: 2021 Mar 26
Other:
Special Notes: doi: 10.1007/s00520-021-06166-0. , Word Count: 240
Objective:
This study aims to evaluate the treatment effect of a mindfulness-based intervention for Chinese breast cancer patients across outcome domains, including symptom-related, psychosocial, and quality of life outcomes.
Methods:
Following the Cochrane Systematic Review guideline, we searched across five electronic databases, reference lists of eligible studies, professional websites, and major academic journals in Chinese. Publication bias was assessed using funnel plot and Vevea and Woods sensitivity analysis, and risk of bias was evaluated using the revised Cochrane risk of bias tool for randomized trials and risk of bias in non-randomized studies of interventions. A meta-analysis of Hedges' g was conducted using meta-regression with robust variance estimation.
Results:
Final analysis included a total of 45 controlled trials containing 286 effect size estimates. Across outcome domains, studies reported an overall large and statistically significant treatment effect, d = 0.921, 95% CI (0.805, 1.040), p < 0.001. Subgroup analyses of specific domains of outcome reported overall significant treatment effects for (1) symptom-related outcomes, d = 0.885, 95% CI (0.657, 1.110), p < 0.001; (2) psychosocial wellness outcomes, d = 0.984, 95% CI (0.879, 1.090), p < 0.001; and (3) quality of life, d = 0.990, 95% CI (0.776, 1.200), p < 0.001. Moderator analysis did not identify any significant moderator.
Conclusion:
Chinese literature reported an overall statistically significant and large treatment effect of a mindfulness-based intervention for breast cancer patients in China. Except for physical symptom outcomes, e.g., nausea/vomiting and pain, a mindfulness-based intervention was effective across outcome domains among Chinese breast cancer patients.
Keywords: Breast cancer; Mindfulness-based intervention; Systematic review and meta-analysis.
PMID: 33770259 DOI: 10.1007/s00520-021-06166-0
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