Effects of Mindfulness-Based Interventions on Fatigue in Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Author: Shelley A Johns1, Will L Tarver2, Ekin Secinti3, Catherine E Mosher3, Patrick V Stutz4, Jennifer L Carnahan4, Tasneem L Talib5, Mackenzie L Shanahan3, Micah T Faidley4, Kelley M Kidwell6, Kevin L Rand3
Affiliation:
1 Indiana University School of Medicine, Regenstrief Institute, Indianapolis, IN, USA. Electronic address: sheljohn@iu.edu.
2 Division of Cancer Prevention and Control, College of Medicine, The Ohio State University, Columbus, OH, USA.
3 Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
4 Indiana University School of Medicine, Regenstrief Institute, Indianapolis, IN, USA.
5 Indiana University School of Nursing, Indianapolis, IN, USA.
6 Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Conference/Journal: Crit Rev Oncol Hematol
Date published: 2021 Mar 3
Other:
Special Notes: doi: 10.1016/j.critrevonc.2021.103290. , Word Count: 154
This systematic review and meta-analysis was designed to determine the efficacy of mindfulness-based interventions (MBIs) in improving fatigue-related outcomes in adult cancer survivors. Randomized controlled trials (RCTs) were identified from PubMed, MEDLINE, PsycINFO, CINAHL, Web of Science, and EMBASE databases and reference lists of included studies. Separate random-effects meta-analyses were conducted for fatigue and vitality/vigor. Twenty-three studies reporting on 21 RCTs (N = 2,239) met inclusion criteria. MBIs significantly reduced fatigue compared to controls at post-intervention (g = 0.60, 95% CI [0.36, 0.83]) and first follow-up (g = 0.42, 95% CI [0.20, 0.64]). Likewise, MBIs significantly improved vitality/vigor at post-intervention (g = 0.39, 95% CI [0.25, 0.52]) and first follow-up (g = 0.35, 95% CI [0.03, 0.67]). The evidence grade was low due to risk of bias, substantial heterogeneity, and publication bias among studies. MBIs show promise in improving fatigue and vitality/vigor in cancer survivors. More rigorous trials are needed to address current gaps in the evidence base.
Keywords: cancer; fatigue; meta-analysis; mindfulness; randomized controlled trial; systematic review; vigor; vitality.
PMID: 33675902 DOI: 10.1016/j.critrevonc.2021.103290
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