The Effect of Pulsed Electromagnetic Fields on Angiogenesis
Author: Lihong Peng1,2, Chenying Fu3, Lu Wang1,2, Qing Zhang1,2, Zejun Liang1,2, Chengqi He1,2, Quan Wei1,2
Affiliation:
1 Department of Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
2 Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, China.
3 State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Conference/Journal: Bioelectromagnetics
Date published: 2021 Mar 6
Other:
Special Notes: doi: 10.1002/bem.22330. , Word Count: 180
A pulsed electromagnetic field (PEMF) has been used to treat inflammation-based diseases such as osteoporosis, neurological injury, and osteoarthritis. Numerous animal experiments and in vitro studies have shown that PEMF may affect angiogenesis. For ischemic diseases, in theory, blood flow may be richer by increasing the number of blood vessels which supply blood to ischemic tissue. PEMF plays a role in enhancing angiogenesis, and their clinical application may go far beyond the current scope. In this review, we analyzed and summarized the effects and possible mechanisms of PEMF on angiogenesis. Most studies have shown that PEMF with specific parameters can promote angiogenesis, which is manifested by an increased vascular growth rate and increased capillary density. The potential mechanisms consist of promoting vascular endothelial cell proliferation, migration, and tube formation, and increasing the expression level of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), angiopoietin-2 (Ang-2), and other angiogenic growth factors. Additionally, PEMF has an impact on the activation of voltage-gated calcium channels (VGCC). Bioelectromagnetics. © 2021 Bioelectromagnetics Society.
Keywords: angiogenesis; endothelial cells; growth factor; pulsed electromagnetic field (PEMF).
PMID: 33675261 DOI: 10.1002/bem.22330
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