Noninvasive Optical Studies of the Brain: Contributions From Systemic Physiology

Author: SergioFantini1 AlexanderRuesch 2 Jana M.Kainerstorfe r2
1 Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, United States
2 Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, United States
Conference/Journal: ScienceDirect
Date published: 2019 Jan
Other: Special Notes: , Word Count: 91

We describe noninvasive, near-infrared spectroscopy measurements of the brain and discuss their sensitivity to systemic physiological changes. We relate those systemic changes to cardiac output, arterial blood pressure, respiration, intracranial pressure, etc., and describe how such contributions to the optical signals may be removed in order to disentangle local responses from systemic influences. We also discuss how such systemic contributions can be used to derive information about cerebrovascular health, for example by pulse oximetry, spiroximetry, and cerebral autoregulation measurements. Experimental designs, signal processing approaches, as well as clinical potential are discussed.