Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation
Author: Dennis Muñoz Vergara1, Lisbeth Berrueta, Colleen Carmody, Xingxing An, Peter M Wayne, Ann Marie Zavacki, Helene M Langevin
Affiliation:
1 From the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (DMV, PMW); National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland (LB); Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (CC, XA, AMZ); and National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland (HML).
Conference/Journal: Am J Phys Med Rehabil
Date published: 2020 Nov 1
Other:
Volume ID: 99 , Issue ID: 11 , Pages: 1012-1019 , Special Notes: doi: 10.1097/PHM.0000000000001465. , Word Count: 202
Objective:
Active stretching of the body is integral to complementary mind-body therapies such as yoga, as well as physical therapy, yet the biologic mechanisms underlying its therapeutic effects remain largely unknown. A previous study showed the impact of active stretching on inflammatory processes in rats. The present study tested the feasibility of using a porcine model, with a closer resemblance to human anatomy, to study the effects of active stretching in the resolution of localized inflammation.
Design:
A total of 12 pigs were trained to stretch before subcutaneous bilateral Carrageenan injection in the back at the L3 vertebrae, 2 cm from the midline. Animals were randomized to no-stretch or stretch, twice a day for 5 mins over 48 hrs. Animals were euthanized for tissue collection 48 hrs postinjection.
Results:
The procedure was well tolerated by the pigs. On average, lesion area was significantly smaller by 36% in the stretch group compared with the no-stretch group (P = 0.03).
Conclusion:
This porcine model shows promise for studying the impact of active stretching on inflammation-resolution mechanisms. These results are relevant to understanding the stretching-related therapeutic mechanisms of mind-body therapies. Future studies with larger samples are warranted.
PMID: 32427602 PMCID: PMC7596692 (available on 2021-11-01) DOI: 10.1097/PHM.0000000000001465
keywords dao yin mawangdui chinese health qigong
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