Brain States and Transitions: Insights from Computational Neuroscience

Author: Morten L Kringelbach1, Gustavo Deco2
1 Department of Psychiatry, University of Oxford, Oxford, UK; Center for Music in the Brain, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Centre for Eudaimonia and Human Flourishing, University of Oxford, Oxford, UK. Electronic address:
2 Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Roc Boronat 138, Barcelona 08018, Spain; Institució Catalana de la Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, Barcelona 08010, Spain; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; School of Psychological Sciences, Monash University, Melbourne, Clayton, VIC 3800, Australia. Electronic address:
Conference/Journal: Cell Rep
Date published: 2020 Sep 8
Other: Volume ID: 32 , Issue ID: 10 , Pages: 108128 , Special Notes: doi: 10.1016/j.celrep.2020.108128. , Word Count: 153

Within the field of computational neuroscience there are great expectations of finding new ways to rebalance the complex dynamic system of the human brain through controlled pharmacological or electromagnetic perturbation. Yet many obstacles remain between the ability to accurately predict how and where best to perturb to force a transition from one brain state to another. The foremost challenge is a commonly agreed definition of a given brain state. Recent progress in computational neuroscience has made it possible to robustly define brain states and force transitions between them. Here, we review the state of the art and propose a framework for determining the functional hierarchical organization describing any given brain state. We describe the latest advances in creating sophisticated whole-brain computational models with interacting neuronal and neurotransmitter systems that can be studied fully in silico to predict and design novel pharmacological and electromagnetic interventions to rebalance them in disease.

PMID: 32905760 DOI: 10.1016/j.celrep.2020.108128