Cortical reorganization processes in meditation naïve participants induced by 7 weeks focused attention meditation training
Author: Lukas Lenhart1, Ruth Steiger2, Michaela Waibel3, Stephanie Mangesius2, Astrid E Grams2, Nicolas Singewald4, Elke R Gizewski2
Affiliation:
1 Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria; Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: lukas.lenhart@i-med.ac.at.
2 Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria; Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria.
3 Yogamood, Innsbruck, Austria.
4 Department of Pharmacology and Toxicology, Institute of Pharmacy and CMBI, Leopold Franzens University, Innsbruck, Austria.
Conference/Journal: Behav Brain Res
Date published: 2020 Jul 31
Other:
Pages: 112828 , Special Notes: doi: 10.1016/j.bbr.2020.112828. , Word Count: 263
PMID: 32745662 DOI: 10.1016/j.bbr.2020.112828
Abstract
Background: Based on the evidence that meditation is associated with numerous beneficial effects on well-being and reduced stress-related symptoms, mindfulness-based techniques were increasingly implemented into psychotherapeutic programs. However, different meditation styles and the cross-sectional nature of most previous analyses resulted in a great variety of morphometric findings. The present study aims to elucidate cortical reorganization processes and altered axonal integrity caused by short-term meditation training, and benefits from solely using focused attention meditation (FAM).
Methods: 3 T MRI, including T1-MPRAGE and diffusion-weighted sequences, was performed in 27 healthy, meditation naïve participants (age: 43 ± 12.4 years) pre and post FAM meditation training (duration: 7.3 ± 0.4 weeks). Voxel-based morphometry was applied to assess brain changes in gray and white matter. Questionnaires were filled out by the individuals at both time-points to evaluate quality of life and self-awareness deficits.
Results: The major findings comprised (i) gray matter increases in the insula, the caudate nucleus and frontal cortices, (ii) decreases in extended parietotemporal regions, the right medial prefrontal cortex and the parahippocampal gyrus, as well as (iii) fractional anisotropy increases of the right hippocampus, the basal ganglia and adjacent regions. Regression analysis revealed an association of specific alterations with reduced levels of state anxiety.
Conclusions: FAM training induced a broad range of dynamic brain alterations even within few weeks of training. Interestingly, this cohort revealed more, and partially different patterns of structural gray matter change compared to prior studies. The broad impact on neuronal organization processes may reflect more general outcomes related to health and well-being.
Keywords: Diffusion-weighted imaging; Focused attention meditation; Gray matter volume; Neuroplasticity.
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