Limitations on electromagnetic communication by vibrational resonances in biological systems

Previous research in biology and physics speculates that high-frequency electromagnetic fields may be an unexplored method of cellular and subcellular communication. The predominant theory for generating electric fields in the cell is mechanical vibration of charged or polar biomolecules such as cell membranes or microtubules. The challenge to this theory is explaining how high-frequency vibrations would not be overdamped by surrounding biological media. As many of these suspected resonators are too large for atomistic molecular dynamics simulations, accurately modeling biological resonators remains an ongoing challenge. While many resonators have been studied and simulated, the general limitations on communication imposed by energy transfer arguments have not been considered. Starting with energy transfer expressions from coupled-mode theory, we derive expressions for the minimum quality factor (Q factor) required to sustain communication for both near- and far-field interactions. We compare previous simulation studies and our theory. We determine the flexing mode of microtubules as an identified resonance in the literature which meets our criteria. Our results suggest the major obstacle to meeting our criteria for effective electromagnetic communication is the trade-off between the Q factor and the plasma frequency: Resonators must be large enough to have a large Q factor, but small enough to resonate at frequencies greater than the plasma frequency.

PMID: 32688526 DOI: 10.1103/PhysRevE.101.062401