The Social Nature of Mitochondria: Implications for Human Health

Author: Martin Picard1 , Carmen Sandi2
1 Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA; Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Electronic address:
2 Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.
Conference/Journal: Neurosci Biobehav Rev
Date published: 2020 Jul 8
Other: Pages: S0149-7634(19)31125-X , Special Notes: doi: 10.1016/j.neubiorev.2020.04.017. , Word Count: 185

Sociality has profound evolutionary roots and is observed from unicellular organisms to multicellular animals. In line with the view that social principles apply across levels of biological complexity, a growing body of data highlights the remarkable social nature of mitochondria - life-sustaining endosymbiotic organelles with their own genome that populate the cell cytoplasm. Here, we draw from organizing principles of behavior in social organisms to reveal that similar to individuals among social networks, mitochondria communicate with each other and with the cell nucleus, exhibit group formation and interdependence, synchronize their behaviors, and functionally specialize to accomplish specific functions within the organism. Mitochondria are social organelles. The extension of social principles across levels of biological complexity is a theoretical shift that emphasizes the role of communication and interdependence in cell biology, physiology, and neuroscience. With the help of emerging computational methods capable of capturing complex dynamic behavioral patterns, the implementation of social concepts in mitochondrial biology may facilitate cross-talk across disciplines towards increasingly holistic and accurate models of human health.

KEYWORDS: Biomarker; Communication; Interdisciplinary; Mitochondrial dynamics; Networks; Psychobiology; Social behavior.

PMID: 32651001 PMCID: PMC8058501 DOI: 10.1016/j.neubiorev.2020.04.017