A Multidimensional and Multi-Feature Framework for Cardiac Interoception

Author: Sol Fittipaldi, Sofía Abrevaya, Alethia de la Fuente, Guido Orlando Pascariello, Eugenia Hesse, Agustina Birba, Paula Salamone, Malin Hildebrandt, Sofía Alarco Martí, Ricardo Marcos Pautassi, David Huepe, Miquel Martorell Martorell, Adrián Yoris, María Roca, Adolfo M García, Lucas Sedeño, Agustín Ibáñez
Author Information:
1 Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Argentina.
2 National Scientific and Technical Research Council (CONICET), Argentina; Buenos Aires Physics Institute (IFIBA) and Physics Department, University of Buenos Aires, Buenos Aires, Argentina; Laboratory of Neuropsychology (LNPS), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
3 National Scientific and Technical Research Council (CONICET), Argentina; Multimedia Signal Processing Group - Neuroimage Division, French-Argentine International Center for Information and Systems Sciences (CIFASIS), National Scientific and Technical Research Council (CONICET), Argentina; Laboratory of Neuroimaging and Neuroscience (LANEN), INECO Foundation Rosario, Argentina.
4 Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Argentina; Departamento de Matemática y Ciencias, Universidad de San Andrés, Buenos Aires, Argentina.
5 Chair for Addiction Research, Institute for Clinical Psychology and Psychotherapy, Dresden, Germany.
6 Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
7 Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina; Instituto de Investigación Médica M. y M. Ferreyra, INIMEC-CONICET-UNC, Córdoba, Argentina.
8 Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile.
9 National Scientific and Technical Research Council (CONICET), Argentina; Laboratory of Neuropsychology (LNPS), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
10 Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Argentina; Faculty of Education, National University of Cuyo (UNCuyo), Mendoza, Argentina.
11 Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Argentina; Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile; Universidad Autónoma Del Caribe, Barranquilla, Colombia; ARC Excellence Center of Cognition and its Disorders, Sydney, Australia. Electronic address: agustin.ibanez@gbhi.org.
Conference/Journal: NeuroImage
Date published: 2020 July 15
Other: Volume ID: 212 , Special Notes: doi: 10.1016/j.neuroimage.2020.116677. , Word Count: 195


Interoception (the sensing of inner-body signals) is a multi-faceted construct with major relevance for basic and clinical neuroscience research. However, the neurocognitive signatures of this domain (cutting across behavioral, electrophysiological, and fMRI connectivity levels) are rarely reported in convergent or systematic fashion. Additionally, various controversies in the field might reflect the caveats of standard interoceptive accuracy (IA) indexes, mainly based on heartbeat detection (HBD) tasks. Here we profit from a novel IA index (md) to provide a convergent multidimensional and multi-feature approach to cardiac interoception. We found that outcomes from our IA-md index are associated with -and predicted by- canonical markers of interoception, including the hd-EEG-derived heart-evoked potential (HEP), fMRI functional connectivity within interoceptive hubs (insular, somatosensory, and frontal networks), and socio-emotional skills. Importantly, these associations proved more robust than those involving current IA indexes. Furthermore, this pattern of results persisted when taking into consideration confounding variables (gender, age, years of education, and executive functioning). This work has relevant theoretical and clinical implications concerning the characterization of cardiac interoception and its assessment in heterogeneous samples, such as those composed of neuropsychiatric patients.

Keywords: Cardiac frequency; Emotion; Functional connectivity; Heart-evoked potential; Heartbeat detection task; Interoception.

PMID: 32101777

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