Effect of Tai Chi Chuan in Breast Cancer Patients: A Systematic Review and Meta-Analysis.

Author: Luo XC1, Liu J2, Fu J3, Yin HY1, Shen L1, Liu ML4, Lan L1,5, Ying J6, Qiao XL6, Tang CZ7, Tang Y1,3,5
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
2Sichuan Provincial People's Hospital, Chengdu, China.
3Medical & Nursing School, Chengdu University, Chengdu, China.
4The School of Acupuncture, Moxibustion & Tuina, Hunan University of Traditional Chinese Medicine, Changsha, China.
5Key Laboratory of Sichuan Province for Acupuncture & Chronobiology, Chengdu, China.
6Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
7School of Acupuncture & Rehabilitation Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Conference/Journal: Front Oncol.
Date published: 2020 Apr 23
Other: Volume ID: 10 , Pages: 607 , Special Notes: doi: 10.3389/fonc.2020.00607. eCollection 2020. , Word Count: 347

Background: Tai Chi Chuan(TCC), as a mind-body exercise, may have a positive impact on physical function and psychological well-being in breast cancer patients. The latest systematic review and meta-analysis of TCC for breast cancer was made 4 years ago and some new clinical trials about it were published. We remade a systematic review and meta-analysis to evaluate the effect of TCC in breast cancer patients. Methods: In this systematic review and meta-analysis, we searched MEDLINE (via PubMed), EMBASE (via embase.com), CENTRAL, CNKI, COVIP, Wanfang, Chaoxing, CiNii, J-SSTAGE, DBpia, and ThaiJO with no language restrictions from inception to December 31, 2018 (updated on February 16, 2020), for randomized clinical trials comparing TCC with non-exercised therapy in breast cancer patients. The primary outcome was quality of life in patients with breast cancer and data pooled by a random-effects model. Subgroup analyses were conducted to estimate the effect of different durations of TCC for breast cancer patients. This study was registered in PROSPERO, number CRD 4201810326. Results: Fifteen articles involving a total of 885 breast cancer participants were included in this review. Compared with non-exercised therapy, TCC had a significant effect on quality of life in breast cancer patients (SMD = 0.37, 95% CI 0.15-0.59, p = 0.001), and subgroup analysis found that TCC showed beneficial effect in 12 weeks and 25 weeks (12 weeks: SMD = 0.40, 95% CI 0.19-0.62, p = 0.0003; 25 weeks: SMD = 0.38, 95% CI 0.15-0.62, p = 0.002). Meta-analyses of secondary outcomes showed that 3 weeks TCC increased shoulder function (SMD = 1.08, 95% CI 0.28-1.87, p = 0.008), 12 weeks TCC improved pain (SMD = 0.30, 95% CI 0.08-0.51, p = 0.007), shoulder function (SMD = 1.34, 95% CI 0.43-2.25, p = 0.004), strength of arm (SMD = 0.44, 95% CI 0.20-0.68, p = 0.0004), and anxiety (MD = -4.90, 95% CI -7.83 to -1.98, p = 0.001) in breast cancer patients compared with the control group. Conclusions: TCC appears to be effective on some physical and psychological symptoms and improves the quality of life in patients with breast cancer. Additional randomized controlled trials with a rigorous methodology and low risk of bias are needed to provide more reliable evidence.

Copyright © 2020 Luo, Liu, Fu, Yin, Shen, Liu, Lan, Ying, Qiao, Tang and Tang.

KEYWORDS: Tai Chi Chuan; breast cancer; meta-analysis; physical and psychological symptoms; quality of life

PMID: 32391277 PMCID: PMC7191057 DOI: 10.3389/fonc.2020.00607