Author: Yu CD1, Xu QJ1, Chang RB2
1Department of Neuroscience, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, United States; Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT 06520, United States.
2Department of Neuroscience, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, United States. Electronic address: firstname.lastname@example.org.
Conference/Journal: Curr Opin Neurobiol.
Date published: 2020 May 4
Other: Volume ID: 62 , Pages: 133-140 , Special Notes: doi: 10.1016/j.conb.2020.03.006. [Epub ahead of print] , Word Count: 142
Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurological, and immunological disorders. Using state-of-the-art technologies including single-cell genomic analysis, real-time neural activity recording, trans-synaptic tracing, and electron microscopy, novel physiological functions of vagal gut afferents have been uncovered, and new gut-to-brain pathways have been revealed. Here, we review the most recent findings on vagal sensory neurons and the gut-brain signaling, focusing on the anatomical basis and the underlying molecular and cellular mechanisms. Such new discoveries explain some of the old puzzling problems and also raise new questions in this exciting and rapidly growing field.
Copyright © 2020 Elsevier Ltd. All rights reserved.
PMID: 32380360 DOI: 10.1016/j.conb.2020.03.006